Stacking the odds for Golgi cisternal maturation.

TitleStacking the odds for Golgi cisternal maturation.
Publication TypeJournal Article
Year of Publication2016
AuthorsMani S, Thattai M
JournalElife
Volume5
Date Published2016 Aug 19
ISSN2050-084X
KeywordsGolgi Apparatus, Models, Biological, Models, Theoretical, Organelle Biogenesis
Abstract

What is the minimal set of cell-biological ingredients needed to generate a Golgi apparatus? The compositions of eukaryotic organelles arise through a process of molecular exchange via vesicle traffic. Here we statistically sample tens of thousands of homeostatic vesicle traffic networks generated by realistic molecular rules governing vesicle budding and fusion. Remarkably, the plurality of these networks contain chains of compartments that undergo creation, compositional maturation, and dissipation, coupled by molecular recycling along retrograde vesicles. This motif precisely matches the cisternal maturation model of the Golgi, which was developed to explain many observed aspects of the eukaryotic secretory pathway. In our analysis cisternal maturation is a robust consequence of vesicle traffic homeostasis, independent of the underlying details of molecular interactions or spatial stacking. This architecture may have been exapted rather than selected for its role in the secretion of large cargo.

DOI10.7554/eLife.16231
Alternate JournalElife
PubMed ID27542195
PubMed Central IDPMC5012865
Grant List500103/Z/09/Z / / Wellcome Trust / United Kingdom
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