Eukaryotes solve the problem of packing diverse physical and chemical processes into a small volume by splitting their intracellular space into membrane-bound organelles. We study the cell biology of organells, interfacing with experiments from yeast, worm, fly, and mammalian cells, as well as in-vitro reconstituted protein-membrane active composites. Major areas of research include:
(i) Dynamics of the cell surface as an active membrane-cytoskeleton composite
(ii) Origin of organelle morphology and spatial distribution
(iii) Evolutionary origins of cellular compartments
(iv) Regulation, information flow, and distributed control of vesicle traffic
Inverse Problems: Lectures I & II
1st Jan 2018
Debsankar Banerjee, Akankshi Munjal, Thomas Lecuit and Madan Rao, Actomyosin pulsation and symmetry breaking flows in a confined active elastomer subject to affine and nonaffine deformations, arXiv:1606.01713 [physics.bio-ph] (2016).
Himani Sachdeva, Mustansir Barma and Madan Rao, Nonequilibrium mechanisms underlying de novo biogenesis of Golgi cisternae, arXiv:1606.01713 [physics.bio-ph] (2016).