Biomolecular complexes and biochemical networks are organized as loosely-constrained assemblies of basic units, whose local degrees of freedom define a high-dimensional configurational landscape. Living systems can use energy to drive these assemblies to functional states. We study how, across experimental contexts, local interactions can be programmed to efficiently funnel energy to desired modes:
(i) Design of protein assemblies
(ii) Biophysics of cellular self-replication
(iii) Tunable in-vitro biomolecular assemblies and biomimetic systems
(iv) Information and control-theoretic principles of programmable landscapes
Old: This interface theme links all the activites of the Simons Centre across scales. We do not have computer science represented directly on our campus. Rather, we use the Simons Centre as a platform to reach out to theoretical computer scientists through our Visitors program, thematic Retreats and Colloquia, and joint students and post-doctoral researchers. The engagement between biology and computer science is nascent globally. We hope to play a critical role in nurturing this interface.
Dynamics Fridays Talk: Long term demographics depend on early stochastic dynamics in growing populations
22nd Dec 2017
Garud Iyengar and Madan Rao, A Cellular Solution to an Information Processing Problem, Proc. Nat. Acad. Sc. 111, 12402-12407 (2014).
Molecular cellular dynamics: Mani, Somya, and Mukund Thattai. "Stacking the odds for Golgi cisternal maturation." eLife 5 (2016): e16231.