Organelle acidification: an ancient cellular leak detector.

TitleOrganelle acidification: an ancient cellular leak detector.
Publication TypeJournal Article
Year of Publication2017
AuthorsThattai M
JournalBMC Biol
Volume15
Issue1
Pagination51
Date Published2017 Jun 26
ISSN1741-7007
KeywordsBiological Evolution, Eukaryotic Cells, Hydrogen-Ion Concentration, Organelles
Abstract

Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to detect and prevent leakage.

DOI10.1186/s12915-017-0395-1
Alternate JournalBMC Biol
PubMed ID28651577
PubMed Central IDPMC5485493
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