Molecular and cellular constraints on vesicle traffic evolution.

TitleMolecular and cellular constraints on vesicle traffic evolution.
Publication TypeJournal Article
Year of Publication2023
AuthorsThattai M
JournalCurr Opin Cell Biol
Date Published2023 Feb
KeywordsBiological Transport, Eukaryotic Cells, Organelles, Proteins, Transport Vesicles

In eukaryotic cells, the budding and fusion of intracellular transport vesicles is carefully orchestrated in space and time. Locally, a vesicle's source compartment, its cargo, and its destination compartment are controlled by dynamic multi-protein specificity modules. Globally, vesicle constituents must be recycled to ensure homeostasis of compartment compositions. The emergence of a novel vesicle pathway therefore requires new specificity modules as well as new recycling routes. Here, we review recent research on local (molecular) constraints on gene module duplication and global (cellular) constraints on intracellular recycling. By studying the evolution of vesicle traffic, we may discover general principles of how complex traits arise via multiple intermediate steps.

Alternate JournalCurr Opin Cell Biol
PubMed ID36610080
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