Title | Assembling anisotropic colloids using curvature-mediated lipid sorting. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Kumar M, Singh A, Del Secco B, Baranov MV, van den Bogaart G, Sacanna S, Thutupalli S |
Journal | Soft Matter |
Volume | 18 |
Issue | 9 |
Pagination | 1757-1766 |
Date Published | 2022 Mar 02 |
ISSN | 1744-6848 |
Keywords | Anisotropy, Colloids, Lipid Bilayers, Protein Transport |
Abstract | The use of colloid supported lipid bilayers (CSLBs) for assembling colloidal structures has been of recent interest. Here, we use multi-component lipid bilayer membranes formed around anisotropic colloids and show that the curvature anisotropy of the colloids drives a sorting of the lipids in the membrane along the colloids. We then exploit this curvature-sensitive lipid sorting to create "shape-anisotropic patchy colloids" - specifically, we use colloids with six rods sticking out of a central cubic core, "hexapods", for this purpose and demonstrate that membrane patches self-assemble at the tip of each of the six colloidal rods. The membrane patches are rendered sticky using biotinylated lipids in complement with a biotin-binding streptavidin protein. Finally, using these "shape-anisotropic patchy colloids", we demonstrate the directed assembly of colloidal links, paving the way for the creation of heterogeneous and flexible colloidal structures. |
DOI | 10.1039/d1sm01517f |
Alternate Journal | Soft Matter |
PubMed ID | 35072193 |