A large part of our effort at the Simons Centre is in exploring new physical and chemical principles underlying biological organization across scales, from functional biomolecules, to subcellular organelles, to the cellular and tissue scale. We are interested in the folding and packaging principles that govern the three dimensional functional organization of large biomolecular assemblies, such as proteins and chromatin, and their interactions with other cellular components. At a larger scale, at the subcellular, cellular and tissue level, organization is driven by active mechanisms fuelled by energy. In many cases, such actively driven organization enables the efficient processing of information, computation and control - tasks that a self-organized living machine has evolved to perform.
Discussion Meeting on Emergence and Evolution of Biological Complexity
4th Feb 2017
Sandeep Krishna (NCBS), Clement Nizak, Philippe Nghe, Sandeep Ameta (ESPCI, Paris), Sudha Rajamani (IISER Pune)
Debsankar Banerjee, Akankshi Munjal, Thomas Lecuit and Madan Rao, Actomyosin pulsation and symmetry breaking flows in a confined active elastomer subject to affine and nonaffine deformations, arXiv:1606.01713 [physics.bio-ph] (2016).
Himani Sachdeva, Mustansir Barma and Madan Rao, Nonequilibrium mechanisms underlying de novo biogenesis of Golgi cisternae, arXiv:1606.01713 [physics.bio-ph] (2016).